Efeito imunoestimulador benéfico da suplementação de Chlorella em curto prazo : aumento da atividade das células Natural Killer e resposta inflamatória precoce (ensaio randomizado, duplo-cego, controlado por placebo)
Jung Hyun Kwak,#1 Seung Han Baek,#2 Yongje Woo,3 Jae Kab Han,4 Byung Gon Kim,4 Oh Yoen Kim,corresponding author5 and Jong Ho Lee
Nutrition Journal - 10.1186/1475-2891-11-53
2012
ABSTRACT
After the 8-week, serum concentrations of interferon-γ (p<0.05) and interleukin-1β (p<0.001) significantly increased and that of interleukin-12 (p<0.1) tended to increase in the Chlorella group. The increments of these cytokines after the intervention were significantly bigger in the Chlorella group than those in the placebo group. In addition, NK cell activities (%) were significantly increased in Chlorella group, but not in Placebo group. The increments of NK cell activities (%) were also significantly bigger in the Chlorella group than the placebo group. Additionally, changed levels of NK cell activity were positively correlated with those of serum interleukin-1β (r=0.280, p=0.047) and interferon-γ (r=0.271, p<0.005). Signficantly positive correlations were also observed among the changed levels of serum cytokines; between interferon-γ and interleukin-1β (r=0.448, p<0.001), between interleukin-12 and interleukin-1β (r=0.416, p=0.003) and between interleukin-12 and interferon-γ (r=0.570, p<001).
Conclusion
These results may suggest a beneficial immunostimulatory effect of short-term Chlorella supplementation which enhances the NK cell activity and produces interferon-γ and interleukin-12 as well as interleukin-1β, the Th-1 cell-induced cytokines in healthy people.
